Epistane, a.k.a. methepitiostane, is a methylated derivative of the Japanese anabolic/anti-estrogenic steroid mepitiostane (thioderon). Its a c-17alpha alkylated (a modification that permits the drug to pass through the liver and into the bloodstream without being deactivated, thereby making it effective for oral administration) steroid thats very similar in actions and effects to the popular dehydrotestosterone-derived Winstrol/Stanozolol and Anavar/Oxandrolone.
Epistane along with its present and former over-the-counter (OTC) chemical cousins like Methyl-1-Testosterone, Superdrol, 1-AD, and numerous others falls into the grey prescription drug/OTC supplement area.
Although they all generate genuine steroidal results (actions and effects), they were never FDA approved for, or sold as a prescription medications. Epistane is marketed in the US (by its actual name) as a sports nutrition supplement, and can be found bottled in quantities of 60 capsules, containing 10 mg of steroid per cap.
For bodybuilding/athletic purposes Epistane increases testosterone levels which induce substantial increases in bodily shape and size, largely due to its ability to increase your number of muscle fibers. Androgens like testosterone also protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones, by inhibiting their ability to send a message to muscle cells to release stored protein. Additionally, testosterone signals muscle cells to store more contractile protein (called actin and myosin) effectively countering the glucocorticoid hormones opposite release protein message. Furthermore, testosterone has the ability to increase erythropoiesis (red blood cell production) within your kidneys, and a higher red blood cell (RBC) count may improve endurance via better oxygenated blood. The presence of more RBCs has also been shown to improve recovery from strenuous physical activity.
The recommended dosage for Epistane users is 10-20 mg/day for 6-8 weeks, which is often enough to keep blood serum levels well above baseline with this particular drug. However, many bodybuilders consume more aggressive dosages of 30 mg/day for 4-6 weeks. It is also safely and effectively administered by women at 5 mg/day for 4-6 wks.
Epistane Side Effects:
There are hosts of possibly nasty, clinically-cited side effects for testosterone usage, many of which are greatly exaggerated by the media. However, the otherwise healthy bodybuilder has much less to worry about regarding side effects.
Epistane’s very low aromatization means you can expect to be virtually free from estrogenic side effects (those due to increases in estrogen estradiol, prolactin, progesterone or progestin) which generally include increased water retention, body fat gain, and gynecomastia (actually due to an imbalance in the testosterone to estrogen ratio).
However, androgenic side effects will be incurred by Epistane users. Androgenic side effects, those having to do with male sexual characteristics, occur due to elevated testosterone levels which are likely to produce oily skin, acne, body/facial hair growth, and testicular atrophy (temporary reduction in the size of your testicles). Androgen drug use of any kind is also known to accelerate balding, but only in men with a genetic predisposition for hair loss. In other words, if youre losing or going to lose your hair then testosterone supplementation can speed up the process, but it is never the primary cause of hair loss.
Your liver and testosterone production may also be affected by Epistane usage. Since its 17-alpha alkylated and therefore hepatotoxic, along with its extreme potency, Epistane warrants a high recommendation for the use of liver detoxification supplements.
Synthetic testosterone and several other steroids, including nandrolones will shut down natural production altogether. A mere 100 mgs per week of either of these takes about 5-6 weeks to cause this shut down, 250-500 mgs shuts you down by the second week, and it takes roughly a month to return those testosterone levels to baseline.
Epistane Chemical Composition
Effective Dose (Men): 10-20 mg/day
Effective Dose (Women): 5 mg/day
Half-Life: Approx. 8 Hours
Detection Time: Unknown
Anabolic/Androgenic Ratio: 1100/91